7/10/2011

Insulin Resistance: The Metabolic Syndrome X (Contemporary Endocrinology) Review

Insulin Resistance: The Metabolic Syndrome X (Contemporary Endocrinology)
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It was in 1986 at the end of his Banting Memorial lecture that Reaven said: "At first blush it appears outlandish to suggest an association between hypertension, hypertriglyceridemia and hyperinsulinemia.." His words have rung in my ears ever since! Yes hyperinsulinemia is now widely understood to be the measurable outcome of insulin resistance, now known by the international acronym "IR". Insulin resistance is the "hidden resistance" that leads to an incredible diversity of clinical disorders which "at first blush" appear even more unlikely; these disorders in fact range from diabetes to polycystic ovary disease; and from hypertension to unwanted facial hair in women to name just four conditions! It is highly appropriate that Reaven has now given the world the benefit of his understanding of this ubiquitous Metabolic Syndrome. This syndrome has baffled science for decades and has lead to an incredidible explosion of research papers on this theme; it is almost impossible to even read and understand all the abstracts for "insulin resistance" on Medline let alone read the published papers! Reaven's book is a welcome addition to our resources.

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